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  EURODIAB PROSPECTIVE COMPLICATIONS STUDY (PCS)
 
 
 
 
The EURODIAB IDDM Complications Study Group have now secured funding to follow-up the original participants of the EURODIAB study.
A cross sectional survey of 3250 people with IDDM in 29 centres in Europe was funded by the EC in 1989-91. In that study, we demonstrated several unique findings. We showed that the relationship between blood pressure and albumin excretion rate differed strikingly between patients with and without retinopathy. In patients without retinopathy, mean AER was normal even when blood pressure was high. We also showed that the prevalence of microalbuminuria was not rare, as commonly supposed, in people who had had IDDM for less than 5 years. For the first time, we demonstrated a clear and consistent adverse effect of smoking on microvascular complications, and also showed that educational status was predictive of diabetes complications. More controversially, we suggested that pregnancy may have a protective effect on microvascular complications in the mother. We will now explore these and other findings in a re-examination of the original cohort, 5-6 years after the baseline examinations. Centres will ascertain the vital status of their participants, and ascertain the cause of death in those who have died. The survivors will be invited to complete a questionnaire on medical events since the original study, lifestyle factors, medication, socioeconomic status, nutrition, pregnancies, the impact of diabetes on their lives, and knowledge about diabetes. They will also undergo a clinical examination, which will include a blood pressure measurement, resting ECG, height, weight and body fat measurements, retinal photography, a neurological examination, a urine collection for estimation of albuminuria, and blood tests for glycated haemoglobin.
 
A centralised information system (CIS) will be designed and implemented by the co- ordinating centre. We will assist all centres in gaining access to the Internet, so that they can readily communicate with us and each other. The CIS will be used for direct data transfer to the co-ordinating centre from the local centres and from the laboratories, and will act as a repository for the final dataset. Local centres, either individually or in groups, will access the dataset locally, and perform their own analyses. Support and training will be provided from the co-ordinating centre. The CIS will also be used to communicate with centres about data queries and study progress, and will also be used as a repository of draft and completed papers by the group and for the template of presentation materials, such as overheads and slides.

Contatti segreteria

Sig.ra Monica Porceddu
E-Mail : asris@tin.it
Fax: 070 - 531947

Dove siamo

S.C. di Diabetologia
Azienda Ospedaliera Brotzu
Via Peretti 2 - 09134 - Cagliari

Donazioni

ASRIS – Onlus
Cc Bancario n. 003919431
ABI 02008
CAB 04814
Presso Banca Unicredit – Dip. Cagliari SD Sole

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